IL-1RA, Interleukin-1RA, rat

Thương hiệu: Bio Basic-Canada   |   Tình trạng: Còn hàng
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IL-1RA, Interleukin-1RA, rat
CAT: RC252-12C
Purity: > 96 % by SDS-PAGE and HPLC analyses.
Storage: (-15 to -20)C

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IL-1RA, Interleukin-1RA, rat
CAT: RC252-12C
Purity: > 96 % by SDS-PAGE and HPLC analyses.
Storage: (-15 to -20)C
Sterile: Yes
Formulation: Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4.

Product Description:IL-1RA, Interleukin-1RA, rat: IL-1RA was initially called the IL-1 inhibitor which is encoded by the IL1RN gene and it is a member of the interleukin 1 cytokine family. IL-1RA is secreted by various types of cells including immune cells, epithelial cells, and adipocytes. IL-RA has functions of inhibiting the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the co-receptor IL1RAP for signaling. IL-1RA is also used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. The rat IL-1RA is a single non-glycosylated polypeptide chain containing 152 amino acids and it has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo. Rat IL-1RA shares 89 % and 73 % a.a. sequence homology with murine and human IL-1RA., UnitProt ID: P25086

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