TNF alpha Variant, Tumor Necrosis Factor-alpha Variant, human

Thương hiệu: Bio Basic-Canada   |   Tình trạng: Còn hàng
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TNF alpha Variant, Tumor Necrosis Factor-alpha Variant, human
CAT: RC214-12V
Purity: >95% by SDS-PAGE and HPLC analyses
Storage: (-15 to -20)C

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TNF alpha Variant, Tumor Necrosis Factor-alpha Variant, human
CAT: RC214-12V
Purity: >95% by SDS-PAGE and HPLC analyses
Storage: (-15 to -20)C
Sterile: Yes
Formulation: Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution in PBS, pH 7.0.

Product Description: TNF alpha Variant, Tumor Necrosis Factor-alpha Variant, human: The clinical use of the potent antitumor activity of TNF-αhas been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-αmutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-α, which binds to the murine TNF-R55 but not to the murine TNF-R75, exhibits retained antitumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors. Based on these results, many TNF-αmutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo., UnitProt ID: P01375

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