TWEAK receptor, human

Thương hiệu: Bio Basic-Canada   |   Tình trạng: Còn hàng
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TWEAK receptor, human
CAT: RC214-23R
Purity: > 95 % by SDS-PAGE and HPLC analyses.
Storage: (-15 to -20)C

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TWEAK receptor, human
CAT: RC214-23R
Purity: > 95 % by SDS-PAGE and HPLC analyses.
Storage: (-15 to -20)C
Sterile: Yes
Formulation: Lyophilized from a 0.2 mm filtered concentrated solution in PBS, pH 7.4

Product Description: TWEAK receptor, human: Human TNF-related weak inducer of apoptosis receptor (TWEAKR) also known as Tumor necrosis factor receptor superfamily member 12A precursor (gene name TNFRSF12A) or fibroblast growth factor-inducable 14 kDa protein, is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAK receptor can be activated by either the membrane anchored or the soluble TWEAK. In addition, It plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. Human and mouse TWEAK R share 82 % a.a. sequence identity.

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